trimethoprim

=Trimethoprim=

How it works
An antibiotic used to kill the bacteria causing your urinary tract infection. //Bacteriostatic; competitively inhibits bacterial folate production essential for bacterial growth.//

Questions to Ask
What medications? //anything that raises potassium (ACEi, supplements)// - medical conditions? //renal impairment// - allergies? //serious allergic reaction to trimethoprim (contraindication)//

How to take
Acute, uncomplicated UTI: //Women//, 300 mg at night for 3 days. //Men//, 300 mg at night for 14 days. Halve in moderate renal impairment

Side effects
common: fever, itch, rash, nausea, vomiting, hyperkalaemia infrequent: sore mouth

Other advice?
hyperkalaemia: Trimethoprim causes potassium retention. Hyperkalaemia can occur with usual doses but is more likely to be clinically significant as dose increases. Average onset is 4–5 days. Risk factors are high dose and renal impairment.

CMI
[|AMH] [|Alprim]