Isosorbide+mononitrate

=Isosorbide mononitrate=

How it works
Imdur belongs to a group of medicines called nitrates. Imdur works by relaxing the blood vessels, letting more blood and oxygen reach the heart. //Provide exogenous source of nitric oxide (which mediates vasodilator effects). Predominantly venodilators; reduce venous return and preload to the heart, reducing myocardial oxygen requirement.//

Questions to Ask
What medications? s//ildenafil, tadalafil or vardenafil, drugs that lower BP (including diuretics)// - medical conditions? //marked anaemia, hypovolaemia// - allergies?

How to take
Initially 30–60 mg once daily, increased up to 120 mg once daily if necessary. Swallow whole; do not crush or chew the tablet. This medicine may make you feel dizzy on standing. Get up gradually from sitting or lying to minimise this effect; sit or lie down if you become dizzy.

Side effects
headache, flushing, palpitations, orthostatic hypotension, fainting, peripheral oedema contact dermatitis (topical), rebound angina
 * Common**
 * Infrequent**

Other advice?

 * take at the time of day when angina is most frequent, eg at night for nocturnal angina or in the morning for daytime angina
 * twice daily dosing with isosorbide mononitrate is not recommended, as there will be no nitrate-free interval and tolerance will be more likely to develop
 * isosorbide mononitrate is not recommended for treatment of acute episodes of angina because of its slow onset of action

CMI
[|Imdur] [|AMH]