Drug+Interactions+With+Nicotine

=Drug Interactions With Nicotine=

Nicotine induces CYP1A2 Enzyme
Smoking cessation will lead to the gradual return of CYP2A1 enzyme to basal level ↓ Less enzyme, will mean less metabolism of substrates metabolised by this enzyme ↓ Less metabolism, means the level of substrate will increase in the body ↓ Increased substrate levels in the body means increased risk of side effect or toxicity



E.g. Caffeine is a substrate of CYP1A2, and when a person quits smoking, their body will retain more caffeine, and as a result they may experience irritability, restlessness and insomnia, which may be mistaken with nicotine withdrawal symptoms. For this reason, you would counsel patients to reduce their caffeine intake when they quit smoking



CYP1A2 Substrates
Caffeine, Theophylline Imipramine, Clomipramine, Fluvoxamine Clozapine, Olanzapine, Tacrine Flecainide, Warfarin

[|For detailed list of CYP1A2 Substrates, Inducers, and Inhibitors (Click Here)]