Statins+and+grapefruit+juice

=Interaction between Statins and Grapefruit juice=

//Grapefruit juice contains one or more components that inhibit CYP3A4 and can increase the plasma levels of drugs metabolised by CYP3A4. The effect of typical consumption (one 250 mL glass daily) is minimal (13% increase in active plasma HMG-CoA reductase inhibitory activity as measured by the area under the concentration time curve) and of no clinical relevance. However, very large quantities (over 1 L daily) significantly increase the plasma levels of HMG-CoA reductase inhibitory activity during simvastatin therapy and should be avoided (see Precautions, Myopathy/ rhabdomyolysis).//

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