fluconazole

=Fluconazole=

How it works
//Fungistatic. Azoles impair the synthesis of ergosterol in fungal cell membranes leading to their breakdown; cell leakage and death occur by lytic activity of the host defence system.//

Questions to Ask
What medications? (inhibits CYP3A4) //carbamazepine, warfarin, NSAIDs// - medical conditions? //risk factors for// prolonged QT interval //(correct underlying cause);// //renal impairment (reduce dose)// - allergies? //azole antifungal (possibility of cross-reactivity)// Drug interactions relate to the use of multiple-dose fluconazole and the relevance to single-dose fluconazole has not yet been established.

Repeat dose contraindicated in pregnancy

How to take
50–200 mg daily (the lower doses are usually used for oral candidiasis).
 * Oropharyngeal/oesophageal candidiasis**

//Treatment//, 150 mg single dose. //Prophylaxis//, initially 2–3 doses of 150 mg given 3 days apart, then 100–150 mg once a week for up to 6 months in severe recurrent cases.
 * Vulvovaginal candidiasis (topical therapy failed)**

=Renal impairment= //Mild-to-moderate//, usual dose for first 2 days, then give half dose daily. //Severe impairment//, seek specialist advice.

but may not matter much if it's a single dose

Side effects
- gastrointestinal disturbances (nausea, abdominal discomfort, diarrhoea, flatulence) Infrequent: anorexia, fatigue

Other advice?
Tell your doctor if you feel unusually tired, nauseous or are not eating, or if you notice dark urine, pale faeces or yellowing of the whites of your eyes or skin.

CMI
[|AMH] [|Diflucan] [|Fluconazole Supply Protocol]: January 2006