Glyceryl+Trinitrate+Patch

=Glyceryl Trinitrate Patch=

How it works
Transiderm-Nitro is used to prevent angina. It is an adhesive patch that delivers a medicine called glyceryl trinitrate through the skin and into the bloodstream. Transiderm-Nitro belongs to a group of medicines called nitrates. Nitrates work by widening blood vessels, letting more blood and oxygen reach the heart. //Provide exogenous source of nitric oxide (which mediates vasodilator effects). Predominantly venodilators; reduce venous return and preload to the heart, reducing myocardial oxygen requirement.//

Questions to Ask
What medications? s//ildenafil, tadalafil or vardenafil, drugs that lower BP (including diuretics)// - medical conditions? //marked anaemia, hypovolaemia// - allergies?

How to take
//Patch//, 5 mg patch for up to 14 hours daily; may be increased up to 15 mg patch.
 * Prevention of chronic angina**

You will normally apply a patch once each day, usually in the morning. Take the patch off for 8 to 12 hours out of every 24 hours (e.g. take it off at bedtime and put a new one on when you wake up in the morning). The best place is your chest but you may use any area except below your knees or elbows. * Choose an area of skin that has no sores, cuts or rashes. If the skin is very hairy, you can clip the hair (do not shave it) so that the patch sticks well and won't be hard to remove. After a shower or bath, wait a few minutes before applying the patch to make sure your skin is completely cool and dry. Bathing, swimming, showering or exercising will usually not affect the patch if it has been correctly applied.
 * How to apply** (full instructions in the [|CMI])

Side effects
headache, flushing, palpitations, orthostatic hypotension, fainting, peripheral oedema contact dermatitis (topical), rebound angina
 * Common**
 * Infrequent**

Other advice?
Ensure a nitrate-free period of 10–12 hours each day with long acting glyceryl trinitrate (patch) to avoid tolerance Stopping this medicine suddenly may bring on attacks of angina, especially if you have been using it for several weeks or more. If you want to stop using it, your doctor will tell you how to do it gradually (e.g. over 4 to 6 weeks) to avoid making your angina worse.

CMI
[|Transiderm-Nitro] [|AMH]