Beta+blocker+recall

=Beta blocker recall=

[|Atenolol] [|Bisoprolol] [|Carvedilol] [|Esmolol] [|Labetalol] [|Metoprolol] [|Oxprenolol] [|Pindolol] [|Propranolol] [|Sotalol]


 * Mode of action**
 * Competitively block beta receptors in heart, peripheral vasculature, bronchi, pancreas, uterus, kidney, brain and liver.
 * Antihypertensive effect due to reduction in cardiac output without reflex increase in peripheral vascular resistance; CNS effect and reduced renin secretion may also contribute.
 * Antianginal effect due to reduction in left ventricular work and oxygen use, resulting from decrease in heart rate and contractility.
 * Antiarrhythmic properties due to antisympathetic effect; depress sinus node function and atrioventricular node conduction, and prolong atrial refractory periods; in addition, some beta-blockers (eg sotalol) prolong action potential duration.
 * Beta1-selective (cardioselective) beta-blockers have a higher affinity for beta1 receptors in the heart, with less effect on beta2 receptors in bronchi and peripheral vasculature; beta1-selectivity diminishes with higher doses.
 * Some beta-blockers (eg oxprenolol, pindolol) have intrinsic sympathomimetic activity (ISA); they can stimulate (partial agonist activity) and block beta receptors.
 * Some beta-blockers with mixed beta-blocking and alpha1-blocking activity (eg labetalol, carvedilol) provide additional arteriolar vasodilating action.


 * Indications**
 * Hypertension
 * Angina (stable and unstable)
 * Arrhythmias
 * MI
 * Heart failure, as an adjunct to conventional treatments
 * Glaucoma, topical

Resources
[|AMH - Beta-blockers]