Bupropion

=Bupropion=



Mode of Action

 * Unknown but may be due to inhibition of Dopamine, NA reuptake

Precautions

 * Can precipitate mania in bi-polar disorder
 * Can increase BP, so monitor BP regularly

Contraindications

 * Allergy to bupropion
 * MAOI previous 14 days

Side Effects
N.B. some of the CNS Side Effects may be related to smoking cessation rather than use of bupropion
 * Dizziness, concentration difficulties, headache
 * Anxiety, agitation
 * Nightmares, tremor, insomnia
 * Nausea
 * Constipation
 * Dry mouth
 * Anorexia
 * Fever
 * Rash, itch, urticaria

Counselling

 * Bupropion takes time to become effective, so start taking Bupropion at LEAST ONE week before you stop smoking
 * Take the medication in the morning to minimise sleep disturbances, and swallow whole with a full glass of water
 * Avoid driving, until you know how the medication affects you
 * Avoid excessive quantities of alcohol while on this medication, as it can increase the risk of unpleasant effects e.g. fits
 * If you develop any signs of allergy e.g. rash, swelling of lips, breathing difficulties STOP taking the medication and seek urgent medical attention